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Costlets: A Generalized Approach to Cost Functions for Automated Optimization...

AbstractWe present the creation and use of a generalized cost function methodology based on costlets for automated optimization for conformal and intensity modulated radiotherapy treatment plans. In...

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Decreased 3D observer variation with matched CT-MRI, for target delineation...

AbstractPurposeTo determine the variation in target delineation of nasopharyngeal carcinoma and the impact of measures to minimize this variation.Materials and methodsFor ten nasopharyngeal cancer...

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Normal Tissue Complications and Protection in Head and Neck Cancer Patients

AbstractIt has been long recognized that radiotherapy, surgery, and chemotherapy for head and neck (H&N) cancer cause a wide range of acute and late morbidities. These effects impact general and...

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Therapeutic Ratio of Reirradiation with Cytotoxic Drugs and Other...

AbstractThe introduction of combined modality approaches was a highly significant step in the evolution of curative radiation treatment. Achieving a favorable balance between tumor cell kill and normal...

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Upper Respiratory and Digestive System: Pharynx, Larynx, and Xerostomia

AbstractThe head and neck includes multiple structures which play a role in deglutition, swallowing, saliva production, and senses. Many of these structures are highly sensitive to various treatment...

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Radiation-Induced Ototoxicity

AbstractHigh-dose radiation therapy for the treatment of head-and-neck tumors, including those of the central nervous system or acoustic schwannomas, can damage components of the auditory...

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When is radiation therapy in head and neck squamous cell carcinoma not...

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When is definitive radiotherapy the preferred treatment for head and neck...

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Management of locally advanced HPV-related oropharyngeal squamous cell...

AbstractHPV-related (HPV+) oropharyngeal cancer (OPC) has a better prognosis compared to HPV unrelated (HPV−) OPC. This review summarizes and discusses several of the controversies regarding the...

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Should patients with laryngeal small cell neuroendocrine carcinoma receive...

AbstractWhile small cell neuroendocrine carcinomas (SCNCs) most often arise in the lung, extrapulmonary SCNCs arise in a variety of locations—including the head and neck region. In particular,...

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A phase II study evaluating axitinib in patients with unresectable, recurrent...

AbstractBackground Axitinib is an oral, potent, small molecule tyrosine kinase inhibitor with selective inhibition of VEGFR 1,2, 3, as well as inhibition of potential downstream effectors of the EGFR...

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Investigating the clinical significance of body composition changes in...

AbstractBackgroundThe purpose is to investigate the clinical significance of body morphomics changes in stage III–IV oropharyngeal cancer patients during concurrent chemoradiotherapy (CRT).MethodsFifty...

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A phase II trial of the BCL-2 homolog domain 3 mimetic AT-101 in combination...

SummaryBackground: AT-101 is a BCL-2 Homolog domain 3 mimetic previously demonstrated to have tumoricidal effects in advanced solid organ malignancies. Given the evidence of activity in xenograft...

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Radiation-induced carotid artery lesions

AbstractPurposeTo review the current aspects of knowledge related to the risk of cerebrovascular events in patients receiving head and neck radiotherapy.MethodsA literature search was performed in...

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Radiation-Induced Sarcomas of the Head and Neck: A Systematic Review

AbstractIntroductionAs a result of the increased use of radiotherapy (RT) and improved long-term overall survival of patients with cancers of the head and neck (HN), the frequency of radiation-induced...

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Management of Older Patients with Head and Neck Cancer: A Comprehensive Review

AbstractThe projected increase in life expectancy over the next few decades is expected to result in a rise in age-related diseases, including cancer. Head and neck cancer (HNC) is a worldwide health...

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A Meta-analysis of Surgical Outcomes of T4a and Infranotch T4b Oral Cancers

AbstractObjectiveTo determine the overall surgical outcomes of infranotch T4b oral cancers and compare them with T4a oral cancers.MethodsPubMed, EMBASE and Cochrane databases from 2000 to 2022 were...

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Intensity-modulated radiation therapy in the treatment of head and neck cancer

Intensity-modulated radiation therapy (IMRT) is a new technical advance in radiotherapy that delivers high dose of radiation to the tumor, while reducing the dose to adjacent non-target tissue, thereby...

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IMRT reduces xerostomia and potentially improves QoL

Xerostomia and reduced quality of life are common occurrences in patients treated with radiation to the salivary gland for head and neck squamous-cell carcinoma. This article discusses outcomes after...

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Organ-sparing radiation therapy for head and neck cancer

Radiation therapy techniques have made great strides over the past decade, both in terms of efficacy and in the avoidance of the associated toxic effects. This Review highlights the particular areas of...

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